2009, discovery of a brand new phenotype for microorganisms in slim nanofluidic slits; and initially detection of area protein buildings together DNA applying solid-state nanopores
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transportation of macromolecules
As a human being, I provide the biblical assignment to explore and use every little thing in development for the good thing about my neighbour. I don't knowledge any conflict involving religion and science. Quite the opposite, my faith stimulates me to complete science, to get open up-minded on the globe.’
Nanofabrication of electrodes with sub-five nm spacing for transport experiments on one molecules and metal clusters
We develop issue-of-treatment diagnostics check of neglected tropical illnesses within useful resource-constrained settings, dependant on Crspr/Cas9 detecting of pathogen’s DNA in overall body fluids.
SMC complexes can go Actual physical roadblocks larger than their ring dimensions, indicating a nontopological mechanism for DNA loop extrusion
A lot of linked developments adopted, wherever our team recognized unique transistor variants which include one-electron transistors at home temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled various transistors into compact evidence-of-basic principle Digital circuits.
Researching DNA loop extrusion by SMC proteins for chromosome architecture with solitary-molecule assays.
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one). The current–voltage curves confirmed substantial modulations with gate voltage, even at home temperature, which was in step ceesdekker.net with band bending in a ~0.6 eV bandgap semiconducting nanotube. These details also showed which the conductance might be modulated by 6 orders of magnitude by altering the gate voltage. The final results of this perform — a home-temperature transistor created from only one carbon nanotube molecule — had been released in Nature in May possibly 1998.
Considering that 2000 he moved to single-molecule biophysics and nanobiology, with exploration from reports of DNA loop extrusion and supercoiling to DNA translocation via nanopores. Additional just lately his research has centered on studying chromatin framework and cell division with microorganisms on chip, whilst he is likewise trying to in the long run Develop artificial cells from the bottom up.
2001, discovery of single-electron transistors at space temperature determined by nanotubes; realization of 1st logic circuits with carbon nanotube products; and discovery with the molecular composition of DNA maintenance enzymes with AFM
Let’s initial search back again in the intervening time after you made a decision to change your focus from superconductivity and nanotubes to biology at the end of the nineties.
Strong-state nanopores have confirmed to become a astonishingly flexible probe for single-molecule Evaluation of DNA. I will explain many of our the latest conclusions – precisely DNA knots – and our endeavours to develop the abilities of reliable-condition nanopores even additional, within the direction of one-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.